Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) developed in Russia as a nootropic agent with applications in cognitive function research. The peptide is a fragment of adrenocorticotropic hormone (ACTH 4-10) with enhanced metabolic stability through the C-terminal Pro-Gly-Pro sequence. Semax modulates brain-derived neurotrophic factor (BDNF) expression and nerve growth factor (NGF) signaling in animal studies of neuroprotection and cognitive enhancement. Regulatory status varies by jurisdiction with approved use as a prescription medication in Russia and investigational status in other markets. Semax is supplied as a nasal spray solution or lyophilized powder for research into cognition, neuroplasticity, and stroke recovery models.
Directory listing last reviewed July 2026.