Semaglutide is a 31-amino acid GLP-1 receptor agonist approved by FDA under brand names Ozempic (injectable, type 2 diabetes), Wegovy (injectable, chronic weight management), and Rybelsus (oral tablet, type 2 diabetes). The peptide is manufactured via solid-phase peptide synthesis using proprietary large-scale SPPS platforms. FDA-approved semaglutide products bear a boxed warning addressing the risk of thyroid C-cell tumors. In 2024-2025, the FDA issued over 50 warning letters targeting unauthorized semaglutide sales, with letters to Prime Vitality/Prime Peptides (December 2024), Xcel Research (December 2024), and USApeptide.com (February 2025) specifically citing unapproved semaglutide products marketed with therapeutic claims. Buyers sourcing semaglutide should verify that suppliers operate under registered FDA establishments with current GMP certification.
Directory listing last reviewed July 2026.